Isabel Clara M-F

Chronic lymphocytic leukaemia

OPTION LIST

A	BCL-2	I	p53
B	CD19	J	Pre-germinal centre cells
C	CD33	K	Cotswold classification
D	ABL	L	T cells
E	Binet	M	Chrorambucil
F	CD117	N	Hairy cells
G	Post-germinal centre cells	O	Haemopoietic blast cells
H	B cells	P	Plasma cells

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. CLL occurs as a result of the abnormal proliferation of a specific mature population of cells.

2. The cell population that proliferates in CLL expresses high levels of a specific marker.

3. The oncogene associated with the structural chromosomal abnormality of 17p in CLL

4. The natural history of CLL correlates with the maturity of the cell of origin. These cells are associated with a poorer prognosis.

5. The system used to stage CLL

ANSWERS

1. H

2. B

3. I

4. J

5. E